Cholinergenic Receptors

02Sep08

Location: Postganglionic fibers of Sympathetic & Parasympathetic ANS, Somatic nervous system

Synthesis and release of Acetylcholine from Cholinergenic neuron

  1. Synthesis of Acetylcholine
    1. Choline + Acetyl CoA –> Acetylcholine + CoA
    2. Inhibited by hemicholinium
  2. Uptake into storage vesicles
    1. Protects Acetylcholine from degradation
  3. Release of neurotransmitter
    1. Steps
      1. Arriving of action potential
      2. Influx of calcium
      3. Difference of charge draws vesicle to presynaptic membrane
      4. Releasing of Acetylcholine to synaptic cleft
    2. Can be blocked by Botolinum Toxin
    3. Some spider venom causes release of Acetylcholine without action potential stimulation
  4. Binding of Acetylcholine to receptor
    1. Cholinergenic receptor
    2. Generates Excitatory Post-Synaptic Potential (EPSP)
  5. Degradation of Acetylcholine
    1. Catalyzed by Acetylcholinesterase
    2. Acetylcholine –> Choline + Acetate
  6. Recycle of Choline
    1. Choline is transported back into presynaptic


No Responses Yet to “Cholinergenic Receptors”

  1. Leave a Comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s


%d bloggers like this: