Physiology of Excitable Tissue


– Ability of all biosystem to answer the stimulation/action of external & internal environment by a change in metabolism.

– Ability of the specialized cells to answer the stimulation by a change in membrane potential or generation on action potential
– Only applicable to nerve, muscle, and certain secretor cells.

– Process of generating action potential.

Components of Excitation
– Chemical
– Physicochemical (Ion permeability)
– Physical (Electric current, temperature)
– Physiological (Change in function properties)

Galvani’s 1st Experiment
– Demonstrate existence metallic current.

Galvani’s 2nd Experiment
– Proves the existence of biological current in living tissue.

Mattencci Experiment
– There are biocurrent between excited & non-excited place.

Resting Potentials
– Formulated by Galvani, Volta, Mattencci, and Du Bois Reymond.
– Resting Membrane Potential (RMP) : Potential difference between the inside & outside the cell.
– 2 kinds of the current:

  • Resting Current: Bioelectric current between damaged & non-damaged site of a membrane.
  • Current of Action: Current between excited & non-excited site of a membrane.

– Consists of:

  • Lipid
  • Protein
    • Integral Proteins
      • Transmembranes
        • Channels
        • Carries
        • Pumps
        • Receptors
      • Enzymes
    •  Peripheral Proteins
      • Cytoskeleton
      • Glycocalyx

– Transport Across Cell Membrane

  • Active
    • Primary : Na-K-ATPase, Ca-ATPase, K-H-ATPase.
    • Secondary : Glucose, Aminoacids, Ca.
  • Passive
    • Diffusion
      • Simple
        • Basic process in which uncharged particles in solution flow downs the concentration gradient.
        • Particles diffuse from high concentration area to low concentration are.
        • Depends on solubility in water or lipid:
          • Lipid-soluble particles diffuse through the membrane directly.
          • Water-soluble particles diffuse through aqueous channel formed by transmembrane proteins.
      • Facilitated
        • Carried-mediated process.
        • Examples: Glucose, Leukocytes, Adipocytes.
        • Insulin as activators.
    • Osmosis
      • Osmotic Pressure Gradient
      • Colloid Oncotic Pressure.
  • Vesicular
    • Endocytosis
    • Exocytosis

32 Responses to “Physiology of Excitable Tissue”

  1. 1 Ralph

    Leave details on origin of MEPP,EPP,IPSP,EPSP and Nmj

  2. Thanks again.

  3. 4 joe

    too shallow…otherwise thanks

  4. Pls try & update site; improvement needed.

    • Thanks for the reminder. I’m currently very busy, as I’ve entered the clinical years. T_T

      Will be glad if anyone want to contribute to this site. Email me whatever content you want to share here (, or if anyone want to co-author this blog, I will be glad to collaborate.

  5. 8 little ejyk

    I like ur work bt make it more comprehensive. Thanks!

  6. 9 little ejyk

    Pls tell me more about Galvani’s 1st & 2nd experiments and Mattencci experiment. Thanks!

  7. 10 henry pascal

    thanks .pls,wake it more comprehensive

  8. 11 henry pascal

    thanks .pls,make it more comprehensive

  9. 12 Berebon frank

    Nice pls make it comprehensive

  10. 13 promise

    hey i just wanted u 2 knw u did a great job in ur text.i really ve a dream of gettn mine in d early years,so.Nice job.

  11. 14 Odetola Tony

    Good work. Please keep it up.

  12. 15 Okpalaugo N. Cephas

    Gud handiwork!

    Just try and get some pics fixed into it.

  13. 16 RubenM


  14. tanks 4 d blog but please cud u make it more comprehensive/?

  15. Very gud article. Pls keep me updated

  16. 19 prince noel okojie

    so where does glucose realy belong, active or passive?

  17. 21 Josephdivine Ande

    A site with basics that need to be expatiated

  18. 22 aijaz wani

    facilitaed comes under active transport(secondary active transport)
    glucose belongs to seciondary active transport….

  19. 23 Shepnaan Dashe .M

    your answers are really concise thanks for that…

  20. Good job,please keep it up!!but do well to make it detail;thanks

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